Sustainably Harvested in Iceland Kerecis is pioneering the use of fish skin in the globally expanding cellular therapy and regenerative medicine market. It is the only approved manufacturer of fish skin based medical devices for tissue regeneration in the world. Kerecis fish skin is a byproduct of the fishing industry in Iceland. The fish are line- caught from sustainable wild fishing stocks in the North Atlantic Ocean. The Kerecis ISO 13485 manufacturing facilities are in the town of Isafjordur in the Westfjords region, 20 miles south of the Arctic Circle, and are powered exclusively by renewable energy. REFERENCES 1) Magnusson, S., et al. Decellularized fish skin: characteristics that support tissue repair. Laeknabladid. 101, 567– 573 (2015). 2) Rakers, S., et al. ‘Fish matters’: the relevance of fish skin biology to investigative dermatology. Exp Dermatol. 19, 313–324 (2010). 3) Baldursson, B. T., et al. Healing rate and autoimmune safety of full- thickness wounds treated with fish skin acellular dermal matrix versus porcine small-intestine submucosa: a noninferiority study. Int J Low Extrem. Wounds. 14, (2015). 4) Kirsner, R. S., et al. Fish skin grafts compared to human amnion/chorion membrane allografts: A double-blind, prospective, randomized clinical trial of acute wound healing. Wound Repair and Regeneration, 28(1), 75-80 (2020). 5) Lullove, E. J., et al. A multicenter, blinded, randomized controlled clinical trial evaluating the effect of Omega-3–rich fish skin in the treatment of chronic, nonresponsive diabetic foot ulcers. Wounds (2021). 6) Winters, C., et al. Cost Effectiveness of Fish Skin Grafts Versus Standard of Care on Wound Healing of Chronic Diabetic Foot Ulcers: A Retrospective Comparative Cohort Study. Wounds. 32(10):283-290.(2020). 7) Stone, II, R., et al. Accelerated Wound Closure of Deep Partial Thickness Burns with Acellular Fish Skin Graft. Int J Mol Sci. 22(4):1590 (2021). 8) Yang, C.K., et al. A Prospective, Postmarket, Compassionate Clinical Evaluation of a Novel Acellular Fish- skin Graft Which Contains Omega-3 Fatty Acids for the Closure of Hard-to- heal Lower Extremity Chronic Ulcers. Wounds. 28(4):112-8 (2016). 9) Trinh, T. T., et al. Marine Omega3 Wound Matrix for the Treatment of Complicated Wounds. Phlebologie. 45, 93–98 (2016). 10) Woodrow, T., et al.Treatment of diabetic foot wounds with acellular fish skin graft rich in omega-3: a prospective evaluation. J Wound Care. 28, 76–80 (2019). 11) Sitje, T. S., et al. A. Clinical innovation: fish-derived wound product for cutaneous wounds. Wounds Int. 2018 9, 44–50 (2018). 12) Patel, M. & Lantis II, J. C. Fish skin acellular dermal matrix: potential in the treatment of chronic wounds. Chronic Wound Care Manag Res. 6, 59–70 (2019). 13) Sibbald, R., et al. Special considerations in wound bed preparation 2011: An update. Adv Skin Wound Care. 24(9):415-36 (2011). 14) Wallner, C., et al. The Use of Intact Fish Skin as a Novel Treatment Method for Deep Dermal Burns Following Enzymatic Debridement: A Retrospective Case-Control Study. Euro Burn J. 3(1):43-55 (2022). 15) Andrews JW, Adams MJ, Montenegro-Johnson TD. A universal scaling law of mammalian touch. Sci Adv. 2020 Oct 9;6(41):eabb6912. doi: 10.1126/sciadv.abb6912. PMID: 33036967; PMCID: PMC7546702. 16) Mauer, E. et al. (2022). Acellular fish skin grafts for the management of wounds in dogs and cats: 17 cases (2019-2021). American Journal of Veterinary Research, 83(2), 188-192. https://doi.org/10.2460/ajvr.21.09.0140 For more information, visit www.jorvet.com or email:
[email protected] Jorgensen Laboratories, LLC Loveland, CO 80538 800.525.5614
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